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KMID : 0355820190400010009
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Korean Journal of Oral Anatomy
2019 Volume.40 No. 1 p.9 ~ p.18
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Disease models for the functional restoration of the periodontium based on developmental biology
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Adhikari Nirpesh
Aryal Yam Prasad
An Chang-Hyeon
Seo Jo-Yeong
An Seo-Young
Kim Jae-Young
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Abstract
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The tooth-supporting structures, which are collectively known as the periodontium, are disrupted in periodontal diseases. This disruption could lead to tooth loss at an advanced state. Therefore, the prevention and management of periodontal diseases are necessary to ensure a good quality of life. Different animal models are used to mimic the human periodontal disease conditions and examine the loss of tissues surrounding the teeth. The efficacy of various therapeutic compounds for the healing and regeneration of the disrupted structures were also examined. However, few studies have used animal models to examine the role of signaling molecules during the process of healing and regeneration. Since the signaling molecules play vital roles during the developmental processes, their role in the healing and regeneration of the periodontium must be evaluated based on the knowledge of developmental biology. This review highlights the process of periodontium development together with the role of signaling molecules. Furthermore, the disease conditions disrupting the periodontium and their severe consequences are also discussed. The different disease models commonly used for evaluation of the therapeutics and signaling molecules in periodontal diseases have also been reviewed, suggesting future research with a developmental biology approach in order to regenerate the periodontium
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KEYWORD
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Periodontium, Experimental model, Periodontitis, Gingivitis, Regeneration
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